Piperidine → HCID 59077630, compound

HRID 1359800Notes

Reaction equation

HRID 1359800 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[CH:23]([C:25]1[NH:29][C:28]([CH3:30])=[C:27]([CH2:31][N:32]2[CH2:37][CH2:36][N:35]([CH:38]=[O:39])[CH2:34][CH2:33]2)[C:26]=1[CH3:40])=O.N1CCCCC1>C(O)C>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:23]\[C:25]1[NH:29][C:28]([CH3:30])=[C:27]([CH2:31][N:32]2[CH2:33][CH2:34][N:35]([CH:38]=[O:39])[CH2:36][CH2:37]2)[C:26]=1[CH3:40])(=[O:12])=[O:11]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 181797685-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-oneHCID 18179913HCID 18179913, compound

Product 1

HCID 59077630HCID 59077630, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one (178 mg) was condensed with 4-(5-formyl-2,4-dimethyl-1H-pyrrol-3-ylmethyl)-piperazine-1-carbaldehyde (125 mg) using piperidine (cat. amount) in ethanol at 80° C. for 4 hours to give the titled compound.

Workup

  1. customat 80° C.
  2. customfor 4 hours

Sources & evidence

ORD record
ord-642e3e014c844300ac41b37453669bb1
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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