反应详情

温度

50 °C

A mixture of (4-fluoro-piperidin-1-yl)-acetonitrile (0.480 mg, 3.2 mmol) in THF 92 mL0 was added to LAH (148 mg, 1.2 eq.) in THF (15 mL). The mixture was heated at 50° C. for 18 hours. The cooled reaction was quenched with NaOH solution until white solid precipitated out. The solid was filtered off and the filtrate was concentrated to give 335 mg (71%) of 2-(4-fluoro-piperidin-1-yl)-ethylamine.

1. customThe cooled reaction
2. customwas quenched with NaOH solution until white solid
3. customprecipitated out
4. filtrationThe solid was filtered off
5. concentrationthe filtrate was concentrated