Trifluoroacetic acid → HCID 69994359, compound

HRID 1359859Notes

Reaction equation

HRID 1359859 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13]([N:15]1[CH2:20][CH2:19][CH:18]([F:21])[CH2:17][CH2:16]1)=[O:14])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:21][CH:18]1[CH2:17][CH2:16][N:15]([C:13]([C@H:9]2[CH2:10][CH2:11][CH2:12][NH:8]2)=[O:14])[CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69996021HCID 69996021, compound

Product 1

HCID 69994359HCID 69994359, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of (R)-2-(4-fluoro-piperidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.5 g, 5 mmol) and TFA (3 mL) in DCM (4 mL) was stirred at rt for one hour to give 1 g of (4-fluoro-piperidin-1-yl)-(R)-pyrrolidin-2-yl-methanone.

Sources & evidence

ORD record
ord-3502feff945147dba657a9ae47bf2cb1
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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