1-[4-(2-Aminoethyl)piperazin-1-yl]ethan-1-one → N-[2-(4-Acetyl-piperazin-1-yl)-ethyl]-2-{5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrol-3-yl}-acetamide

HRID 1359876Notes

Reaction equation

HRID 1359876 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:23]\[C:24]1[NH:28][C:27]([CH3:29])=[C:26]([CH2:30][C:31]([OH:33])=O)[C:25]=1[CH3:34])(=[O:12])=[O:11].[NH2:35][CH2:36][CH2:37][N:38]1[CH2:43][CH2:42][N:41]([C:44](=[O:46])[CH3:45])[CH2:40][CH2:39]1>>[C:44]([N:41]1[CH2:42][CH2:43][N:38]([CH2:37][CH2:36][NH:35][C:31](=[O:33])[CH2:30][C:26]2[C:25]([CH3:34])=[C:24](/[CH:23]=[C:16]3\[C:17](=[O:22])[NH:18][C:19]4[C:15]\3=[CH:14][C:13]([S:10]([CH2:9][C:3]3[C:4]([Cl:8])=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])(=[O:11])=[O:12])=[CH:21][CH:20]=4)[NH:28][C:27]=2[CH3:29])[CH2:39][CH2:40]1)(=[O:46])[CH3:45]

Participants

3

Reactant 2

HCID 167857031-[4-(2-Aminoethyl)piperazin-1-yl]ethan-1-oneHCID 59077497HCID 59077497, compound

Product 1

HCID 59077649N-[2-(4-Acetyl-piperazin-1-yl)-ethyl]-2-{5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrol-3-yl}-acetamide

Procedure

{5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrol-3-yl}-acetic acid was coupled with 1-[4-(2-amino-ethyl)-piperazin-1-yl]-ethanone to give the titled compound.

Sources & evidence

ORD record
ord-711d1ca965114bdd8f2fcc37745aba9b
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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