Methylamine → HCID 59780173, compound

HRID 1359901Notes

Reaction equation

HRID 1359901 reaction equation
[OH:1][CH:2]([CH:22]=[CH2:23])[CH:3]([NH:9][C:10]([C:12]1[C:13]([C:18]([F:21])([F:20])[F:19])=[N:14][N:15]([CH3:17])[CH:16]=1)=[O:11])[C:4]([O:6]CC)=O.[CH3:24][NH2:25]>CO>[OH:1][CH:2]([CH:22]=[CH2:23])[CH:3]([NH:9][C:10]([C:12]1[C:13]([C:18]([F:19])([F:20])[F:21])=[N:14][N:15]([CH3:17])[CH:16]=1)=[O:11])[C:4](=[O:6])[NH:25][CH3:24]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 59780172HCID 59780172, compound

Product 1

HCID 59780173HCID 59780173, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.65 g (4.92 mmol) of ethyl 3-hydroxy-2-[(1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)amino]pent-4-enoate were dissolved in methanol. At 0° C., methylamine gas was introduced for 1 h. After 16 h of stirring at RT, the solvent was removed and the residue was recrystallized from acetone. The precipitate gave 0.65 g of erythro title compound as a colorless powder, the filtrate contained 0.75 g of isomer mixture. Accordingly, the total yield was 1.40 g (89% of theory).

Workup

  1. customthe solvent was removed
  2. customthe residue was recrystallized from acetone

Sources & evidence

ORD record
ord-dd95b82b5e4c4811877900da96f735cf
Source dataset
uspto-grants-2011_02
Patent number
US07879761B2

Reaction notes

Loading…