反应详情

A solution of D-Homophenylalanine hydrochloride (1.7 g, 7.93 mmol), benzyl alcohol (7.2 mL, 64.0 mmol) and p-toluenesulfonic acid monohydrate (1.8 g, 9.5 mmol) in benzene (30 mL) was heated at reflux in Dean Stark apparatus during 5 hrs, after which time additional benzene (100 mL) was distilled from reaction mixture. The residue was triturated with diethyl ether, the solid was filtered and dried to give title product (2.93 g).

1. temperatureat reflux in Dean Stark apparatus during 5 hrs
2. distillationafter which time additional benzene (100 mL) was distilled from reaction mixture
3. customThe residue was triturated with diethyl ether
4. filtrationthe solid was filtered
5. customdried