反应详情

N-Boc-D-homophenylalanine Quinoline-3-amide (2.6 g, 6.42 mmol, procedure 1A) was treated with trifluoroacetic acid (15 mL) at 25° C. for 1 hr. The solution was concentrated to dryness and treated with diethyl ether (10 mL). The solid was filtered and dried. It was dissolved in water (180 mL) and neutralized to pH=7.5 with saturated solution of sodium bicarbonate. The mixture was stirred for 1 hr and the solid was filtered and dried giving the title compound (1.30 g) as white solid.

1. concentrationThe solution was concentrated to dryness
2. additiontreated with diethyl ether (10 mL)
3. filtrationThe solid was filtered
4. customdried
5. dissolutionIt was dissolved in water (180 mL)
6. filtrationthe solid was filtered
7. customdried