反应详情

A solution (0.18 M) of tert-butyl 5-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate in THF was treated with TBAF (1.1 eq) at 0° C. The mixture was stirred at that temperature for 10 min and allowed to reach room temperature. The reaction was quenched by the addition of saturated aqueous NH4Cl solution and extracted with ethyl acetate. The organic layer was washed with H2O, brine and dried over Na2SO4. The crude product was purified by column chromatography on silica gel (Petroleum ether:EtOAc 92/8) to afford the title compound as a colorless oil.

1. customto reach room temperature
2. customThe reaction was quenched by the addition of saturated aqueous NH4Cl solution
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with H2O, brine
5. dry with materialdried over Na2SO4
6. customThe crude product was purified by column chromatography on silica gel (Petroleum ether:EtOAc 92/8)