Acetate → HCID 21076045, compound

HRID 1359963Notes

Reaction equation

HRID 1359963 reaction equation
Cl.[CH2:2]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]([OH:13])=[O:12])[CH:6]=1)[CH2:3][CH3:4].[H][H].C([O-])(=O)C>C(O)(=O)C.[Pt](=O)=O>[CH2:2]([CH:5]1[CH2:10][CH2:9][NH:8][CH:7]([C:11]([OH:13])=[O:12])[CH2:6]1)[CH2:3][CH3:4]

Participants

6

Reactant 3

HCID 175AcetateHCID 66862602HCID 66862602, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21076045HCID 21076045, compoundYield 1,107.6%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

Platinum(IV) oxide (79.8 mg, 0.35 mmol) was added to a solution of 1.05 g (5.22 mmol) of 4-propylpyridine-2-carboxylic acid hydrochloride synthetized according to a literature (J. Med. Chem. 1984, 27, 216.) in acetic acid (8 ml), and the mixture was stirred in a hydrogen atmosphere under the atmospheric pressure overnight. The reaction solution was filtered through Celite, and the solvent was then removed by distillation to give 9.90 g (yield 90%) of the title compound as acetate.

Workup

  1. filtrationThe reaction solution was filtered through Celite
  2. customthe solvent was then removed by distillation

Sources & evidence

ORD record
ord-8dccff2a4b8947dcb25840c39b28ead7
Source dataset
uspto-grants-2011_02
Patent number
US07879808B2

Reaction notes

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