HCID 66782073, compound → HCID 66781649, compound

HRID 1360147Notes

Reaction equation

HRID 1360147 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH3:19])[CH2:14][O:13][CH2:12]/[C:11](=[CH:15]/[N+:16]([O-])=O)/[NH:10]2)=[CH:5][CH:4]=1>[Ni].O1CCCC1.CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2([CH3:19])[NH:10][CH:11]([CH2:15][NH2:16])[CH2:12][O:13][CH2:14]2)=[CH:7][CH:8]=1

Participants

5

Reactant 1

HCID 66782073HCID 66782073, compound

Product 1

HCID 66781649HCID 66781649, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 50 mmol of 3-(4-methoxyphenyl)-3-methyl-5-[1-nitrometh-(Z)-ylidene]morpholine and 5 teaspoons full of Raney nickel in 500 ml of tetrahydrofuran and 250 ml of methanol is hydrogenated under atmospheric pressure for 5 hours. The reaction mixture is filtered through Hyflo and the filtrate is evaporated. The crude title compound is identified from the residue on the basis of the Rf. The title compound is employed without further purification in the next stage.

Workup

  1. filtrationThe reaction mixture is filtered through Hyflo
  2. customthe filtrate is evaporated
  3. customThe title compound is employed without further purification in the next stage

Sources & evidence

ORD record
ord-f98da48952de42a08eaf7bd6c7033fcf
Source dataset
uspto-grants-2011_02
Patent number
US07879847B2

Reaction notes

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