反应详情

After 4-(4-methoxyphenyl)-4-oxobutanoic acid (40 g) was added to (not completely dissolved in) a mixed solvent of acetic acid (100 ml) and THF (100 ml), 10% palladium-carbon (50%-wet) (4 g) was added thereto and the resulting mixture was stirred for 9 hours under a hydrogen atmosphere (0.4 MPa). The catalyst was removed by filtration through Celite and toluene was added to the residue. The solvent was distilled off under reduced pressure to obtain 4-(4-methoxy-phenyl)butanoic acid quantitatively.

1. additionwas added
2. customThe catalyst was removed by filtration through Celite and toluene
3. additionwas added to the residue
4. distillationThe solvent was distilled off under reduced pressure