HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloropyrimidine → HCID 59818073, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl (4-aminophenyl)carbamate | HCID 688611 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 59818073 | HCID 59818073 | — |
Reaction Steps
4,6-Dichloropyrimidine (14.89 g, 0.1 mol), N-Boc-1,4-phenylenediamine (20.83 g, 0.1 mol) and diisopropylethylamine (17.11 mL, 0.1 mol) are heated in n-butanol (160 mL) for 20 h at 90° C. After evaporation, the residue is extracted and purified by crystallization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879853B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-403f1be223c040f28239c260e476f63f |
| Source note | uspto-grants-2011_02 |