4,6-Dichloropyrimidine → HCID 59818073, compound

HRID 1360350Notes

Reaction equation

HRID 1360350 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[C:9]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=1)([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].C(N(C(C)C)CC)(C)C>C(O)CCC>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:23][C:20]2[CH:19]=[CH:18][C:17]([NH:16][C:9](=[O:10])[O:11][C:12]([CH3:14])([CH3:13])[CH3:15])=[CH:22][CH:21]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 709434,6-DichloropyrimidineHCID 81531DiisopropylethylamineHCID 688611tert-Butyl (4-aminophenyl)carbamate

Product 1

HCID 59818073HCID 59818073, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

4,6-Dichloropyrimidine (14.89 g, 0.1 mol), N-Boc-1,4-phenylenediamine (20.83 g, 0.1 mol) and diisopropylethylamine (17.11 mL, 0.1 mol) are heated in n-butanol (160 mL) for 20 h at 90° C. After evaporation, the residue is extracted and purified by crystallization.

Workup

  1. customAfter evaporation
  2. extractionthe residue is extracted
  3. custompurified by crystallization

Sources & evidence

ORD record
ord-403f1be223c040f28239c260e476f63f
Source dataset
uspto-grants-2011_02
Patent number
US07879853B2

Reaction notes

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