HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 6-Cyanopyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-Carbamoylpyridine-2-carboxylic acid | HCID 18676698 | — |
| Product | 6-Cyanopyridine-2-carboxylic acid | HCID 21253039 | — |
Reaction Steps
6-Carbamoyl-pyridine-2-carboxylic acid (compound G1) (500 mg, 3 mmol) and phosphorus oxychloride (POCl3) (15 mL) are heated to reflux temperature for 2 h. The mixture is worked up in the usual manner and the crude product is further used without any purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879853B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-f96aad530e67451382ebe34338fb2cad |
| Source note | uspto-grants-2011_02 |