Phosphorus oxychloride → 6-Cyanopyridine-2-carboxylic acid

HRID 1360360Notes

Reaction equation

HRID 1360360 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[CH:6][CH:5]=1)(=O)[NH2:2].P(Cl)(Cl)(Cl)=O>>[C:1]([C:4]1[N:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[CH:6][CH:5]=1)#[N:2]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 186766986-Carbamoylpyridine-2-carboxylic acid

Product 1

HCID 212530396-Cyanopyridine-2-carboxylic acid

Procedure

6-Carbamoyl-pyridine-2-carboxylic acid (compound G1) (500 mg, 3 mmol) and phosphorus oxychloride (POCl3) (15 mL) are heated to reflux temperature for 2 h. The mixture is worked up in the usual manner and the crude product is further used without any purification.

Workup

  1. temperatureto reflux temperature for 2 h
  2. customthe crude product is further used without any purification

Sources & evidence

ORD record
ord-f96aad530e67451382ebe34338fb2cad
Source dataset
uspto-grants-2011_02
Patent number
US07879853B2

Reaction notes

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