Ammonia → 5-carbamoylpyridine-3-carboxylic acid

HRID 1360361Notes

Reaction equation

HRID 1360361 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([O-:9])=[O:8])[CH:4]=[C:3]([C:10]([O:12]CC2C=CC=CC=2)=O)[CH:2]=1.[NH3:20]>>[C:10]([C:3]1[CH:2]=[N:1][CH:6]=[C:5]([CH:4]=1)[C:7]([OH:9])=[O:8])(=[O:12])[NH2:20]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 713530155-[(Benzyloxy)carbonyl]pyridine-3-carboxylate

Product 1

HCID 3366825-carbamoylpyridine-3-carboxylic acid

Procedure

Monobenzyl pyridine-3,5-dicarboxylate (compound G2) (1.92 g, 7.5 mmol) is heated in aqueous concentrated ammonia solution (40 mL, 25%) to 90° C. for 6 h. After cooling, the solution is evaporated and the residue is used as crude product without further purification.

Workup

  1. temperatureAfter cooling
  2. customthe solution is evaporated
  3. customthe residue is used as crude product without further purification

Sources & evidence

ORD record
ord-c4c7447aed4642a98694c1bb33a1f2bd
Source dataset
uspto-grants-2011_02
Patent number
US07879853B2

Reaction notes

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