Chlorotrimethylsilane → Tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

HRID 136041Notes

Reaction equation

HRID 136041 reaction equation
[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH:14]([C:19](=[O:20])[OH:21])[CH:15]([OH:18])[CH2:16][CH2:17]1.[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:1][Si:2]([Cl:3])([CH3:4])[CH3:5]>>[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH:14]([CH2:19][OH:20])[CH:15]([OH:18])[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 140370151-((Tert-butoxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

Product 1

HCID 14436245Tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-e05d14b73db64f2ea7290dd84dd4e58c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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