反应详情

A mixture of ethyl 1,5-diethyl-1H-pyrazole-3-carboxylate (29.4 g, 0.150 mol) and ammonium hydroxide (150 mL of 30%) was stirred overnight at ambient temperature. An analysis by thin layer chromatography (TLC) indicated the reaction was incomplete. The reaction was then heated for 14 hours at 125° C. in a pressure vessel, allowed to cool to ambient temperature, and cooled to 0° C. A precipitate formed, was isolated by filtration, and washed with cold hexanes to provide 8.3 g of 1,5-diethyl-1H-pyrazole-3-carboxamide as a white solid, mp 129-131° C.

1. temperatureThe reaction was then heated for 14 hours at 125° C. in a pressure vessel
2. temperatureto cool to ambient temperature
3. temperaturecooled to 0° C
4. customA precipitate formed
5. customwas isolated by filtration
6. washwashed with cold hexanes