Methylhydrazine → Ethyl 5-(4-chlorobutyl)-1-methyl-1H-pyrazole-3-carboxylate

HRID 1360504Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1360504
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=O)[CH3:7].[C:9](OCC)(=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11].[CH3:19][NH:20][NH2:21]>>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[N:20]([CH3:19])[N:21]=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=1

Komponenten

4

Edukt 3

HCID 6061MethylhydrazineHCID 7268Diethyl OxalateHCID 824686-Chlorohexan-2-one

Produkt 1

HCID 66959070Ethyl 5-(4-chlorobutyl)-1-methyl-1H-pyrazole-3-carboxylate

Versuchsvorschrift

Ethyl 5-(4-chlorobutyl)-1-methyl-1H-pyrazole-3-carboxylate was prepared from 6-chloro-2-hexanone (50.0 g, 357 mmol) and diethyl oxalate (48.4 mL, 357 mmol) according to the procedure described in Part A of Example 19 using methyl hydrazine (19.0 mL, 357 mmol) in place of ethylhydrazine oxalate. Ethyl 5-(4-chlorobutyl)-1-methyl-1H-pyrazole-3-carboxylate was isolated as a dark oil that was used without purification in the next step.

Quellen und Nachweise

ORD-Eintrag
ord-f5d5f6fd0f25403e80e54e95daccd711
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879849B2

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