Hydrochloric Acid → HCID 66959059, compound

HRID 1360517Notes

Reaction equation

HRID 1360517 reaction equation
[CH2:1]([C:5]1[N:6](C(C)(C)C)[N:7]=[C:8]2[C:17]=1[C:16]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:10]=[C:9]2[NH2:18])[CH2:2][CH2:3][CH3:4].[ClH:23]>O>[ClH:23].[CH2:1]([C:5]1[NH:6][N:7]=[C:8]2[C:17]=1[C:16]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:10]=[C:9]2[NH2:18])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57717593HCID 57717593, compound

Product 1

HCID 66959059HCID 66959059, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1-butyl-2-tert-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine (prepared as described in Example 43, 1.43 g, 4.60 mmol) in 6 M HCl in water (40 mL) was heated at 100° C. overnight. The reaction mixture was allowed too cool to room temperature and a white solid was isolated by filtration, washed with water to provide 1-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine hydrochloride that was used in the next step without extensive drying. Alternatively, the product can be dried in a vacuum oven at 95° C.

Workup

  1. customa white solid was isolated by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-173371c0d7ad495297e53c553c74a1cf
Source dataset
uspto-grants-2011_02
Patent number
US07879849B2

Reaction notes

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