Bromide ion → Ethyl 4-(4-hydroxy-1-piperidyl)-4-methyl-piperidine-1-carboxylate

HRID 136055Notes

Reaction equation

HRID 136055 reaction equation
[Br-:21].[C:1](#[N:2])[C:3]1([N:14]2[CH2:15][CH2:16][CH:17]([OH:20])[CH2:18][CH2:19]2)[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[CH2:7][CH2:8]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:22][Mg+:23].[CH3:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>>[CH3:1][C:3]1([N:14]2[CH2:15][CH2:16][CH:17]([OH:20])[CH2:18][CH2:19]2)[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[CH2:7][CH2:8]1

Participants

6

Reactant 5

HCID 259Bromide ionHCID 1140TolueneHCID 8028Tetrahydrofuran2×HCID 57619806Ethyl 4-cyano-4-(4-hydroxy-1-piperidyl)piperidine-1-carboxylateHCID 178477777HCID 178477777, compound

Product 1

HCID 57619818Ethyl 4-(4-hydroxy-1-piperidyl)-4-methyl-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-2fabfcb9890f407c94031d7838bfb38b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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