Hydrochloric Acid → 1-(2-aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine

HRID 1360580Notes

Reaction equation

HRID 1360580 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][C:6]1[N:7]([CH2:20][CH2:21][CH3:22])[N:8]=[C:9]2[C:18]=1[C:17]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:11]=[C:10]2[NH2:19].[OH-].[Na+].Cl>>[NH2:3][CH2:4][CH2:5][C:6]1[N:7]([CH2:20][CH2:21][CH3:22])[N:8]=[C:9]2[C:18]=1[C:17]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:11]=[C:10]2[NH2:19]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 669590441-(2-aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine dihydrochloride

Product 1

HCID 669583921-(2-aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Procedure

1-(2-Aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine dihydrochloride, prepared according to the method described in Parts A through H of Example 51 was stirred with aqueous sodium hydroxide at pH 13. The mixture was adjusted to pH 8 with the addition of hydrochloric acid, and the resulting mixture was extracted with dichloromethane. The extracts were concentrated under reduced pressure to provide 1-(2-aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine.

Workup

  1. extractionthe resulting mixture was extracted with dichloromethane
  2. concentrationThe extracts were concentrated under reduced pressure

Sources & evidence

ORD record
ord-c940576ec0a542c593a85966e71c9ad6
Source dataset
uspto-grants-2011_02
Patent number
US07879849B2

Reaction notes

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