2-Methoxy-1-Pyrroline → HCID 178472171, compound

HRID 1360654Notes

Reaction equation

HRID 1360654 reaction equation
CO[C:3]1[CH2:4][CH2:5][CH2:6][N:7]=1.[O:8]=[C:9]([C:16]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=1[F:24])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>C(N(CC)CC)C>[O:8]=[C:9]([C:16]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=1[F:24])[C:10](=[C:3]1[CH2:4][CH2:5][CH2:6][NH:7]1)[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 3534432-Methoxy-1-PyrrolineHCID 2758933Ethyl 2,4,5-trifluorobenzoylacetate

Product 1

HCID 178472171HCID 178472171, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Conditions

Temperature
60 °C

Procedure

5-Methoxy-3,4-dihydro-2H-pyrrole and triethylamine were added to ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate, for stirring at 60° C. for 4 days, to obtain ethyl 3-oxo-2-pyrrolidin-2-ylidene-3-(2,4,5-trifluorophenyl)propanoate.

Sources & evidence

ORD record
ord-d641056427b242d78a03df27cd978300
Source dataset
uspto-grants-2011_02
Patent number
US07879878B2

Reaction notes

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