HCID 57700380, compound → HCID 57700381, compound

HRID 1360667Notes

Reaction equation

HRID 1360667 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH:8]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:20])[C:9](=[O:12])[C:10]#[CH:11])[CH:5]=[CH:4][CH:3]=1>N1C=CC=CC=1>[Cl:1][C:2]1[N:7]2[C:6]([CH:5]=[CH:4][CH:3]=1)=[C:8]([C:13]1[C:14]([Cl:20])=[CH:15][CH:16]=[CH:17][C:18]=1[Cl:19])[C:9](=[O:12])[CH:10]=[CH:11]2

Participants

3

Reactant 1

HCID 57700380HCID 57700380, compound

Product 1

HCID 57700381HCID 57700381, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 1-(6-chloropyridin-2-yl)-1-(2,6-dichlorophenyl)but-3-yn-2-one (Step A above, 102 mg) in pyridine (7 mL) was heated to 90° C. for about 1½ hr and cooled to room temperature. The mixture was evaporated and purified by silica gel (methylene chloride/acetone=3/1) to give desired product as a yellowish solid (90 mg).

Workup

  1. customThe mixture was evaporated
  2. custompurified by silica gel (methylene chloride/acetone=3/1)

Sources & evidence

ORD record
ord-b66f0d6ce34a428db2e5c6bb77114ff0
Source dataset
uspto-grants-2011_02
Patent number
US07879875B2

Reaction notes

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