Sodium borohydride → HCID 16064296, compound

HRID 1360669Notes

Reaction equation

HRID 1360669 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:10](=[O:27])[CH:11]=[CH:12][N:13]2[C:18]=1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH:21]=[O:22].[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:10](=[O:27])[CH:11]=[CH:12][N:13]2[C:18]=1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH2:21][OH:22]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 16064290HCID 16064290, compound

Product 1

HCID 16064296HCID 16064296, compoundYield 49.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[1-(2,6-dichlorophenyl)-2-oxo-2H-quinolizin-6-yl]benzaldehyde (Example 4, 8 mg) in methanol was added sodium borohydride (2 mg) at 0° C. and stirred for ½ hr. The mixture was concentrated and purified by silica gel (methylene chloride/acetone=1/2) to give the title compound (4 mg).

Workup

  1. concentrationThe mixture was concentrated
  2. custompurified by silica gel (methylene chloride/acetone=1/2)

Sources & evidence

ORD record
ord-303f092237e84b748ff41e59ec0f6848
Source dataset
uspto-grants-2011_02
Patent number
US07879875B2

Reaction notes

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