HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(2,4-Difluorophenyl)-1-(2,6-difluorophenyl)-2H-quinolizin-2-one → HCID 16064458, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(2,4-Difluorophenyl)-1-(2,6-difluorophenyl)-2H-quinolizin-2-one | HCID 16064456 | — |
| Reactant | Bromine dichloromethane | HCID 86630468 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 16064458 | HCID 16064458 | — |
Reaction Steps
To a solution of 6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2H-quinolizin-2-one (Example 11, 78 mg, 0.211 mmol) in CH2Cl2 was added a solution of Br2:CH2Cl2 (1:1) at room temperature. The reaction was stirred for a couple hours until complete by LCMS. The reaction mixture was concentrated in vacuo and the crude material was purified via silica gel chromatography (100% EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879875B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-91c6e37deb594d64bfd8187e0f8ec07e |
| Source note | uspto-grants-2011_02 |