Pyridine, 2,4,6-trichloro- → 2,6-Dichloro-4-methoxypyridine

HRID 1360673Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1360673
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.C[O-].[Na+].[C:13](OCC)(=[O:15])C.O>CO>[Cl:1][C:2]1[CH:7]=[C:6]([O:15][CH3:13])[CH:5]=[C:4]([Cl:9])[N:3]=1

Komponenten

5

Edukt 3

HCID 27665Pyridine, 2,4,6-trichloro-HCID 10942334Sodium MethoxideHCID 22728543Water ethylacetate

Produkt 1

HCID 33199932,6-Dichloro-4-methoxypyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2,4,6-trichloropyridine (4.5 g) in methanol was added sodium methoxide (25% in methanol, 6.8 mL) at room temperature. The mixture was stirred for 12 h then poured into ethyl acetate/water and separated. The organic layer was washed with water, brine and dried over magnesium sulfate. Upon evaporating, the residue was purified by crystallization (100% hexanes) to give title compound as solid (3.1 g).

Aufarbeitung

  1. customseparated
  2. washThe organic layer was washed with water, brine
  3. dry with materialdried over magnesium sulfate
  4. customUpon evaporating
  5. customthe residue was purified by crystallization (100% hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-f5b3f16c56ba46f48aa34f6b160730c0
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879875B2

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