反应详情

To a solution of 2,4,6-trichloropyridine (4.5 g) in methanol was added sodium methoxide (25% in methanol, 6.8 mL) at room temperature. The mixture was stirred for 12 h then poured into ethyl acetate/water and separated. The organic layer was washed with water, brine and dried over magnesium sulfate. Upon evaporating, the residue was purified by crystallization (100% hexanes) to give title compound as solid (3.1 g).

1. customseparated
2. washThe organic layer was washed with water, brine
3. dry with materialdried over magnesium sulfate
4. customUpon evaporating
5. customthe residue was purified by crystallization (100% hexanes)