HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 16065042, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 16064900 | HCID 16064900 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 16065042 | HCID 16065042 | — |
Reaction Steps
To a solution of 4-[6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl]-3,5-difluorobenzoic acid (Example 38) in NMP was added EDC, HOBT and ammonium hydroxide. After reaction complete, the mixture was concentrated and purified by reverse phase chromatography (10-100% ACN in H2O, Kromisil, C8, 30×100 mm) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879875B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-34078cee26cd424dadaaf874424172d7 |
| Source note | uspto-grants-2011_02 |