反应详情

To a solution of 1-(2,6-difluorophenyl)-1-[6-(2,4-difluorophenyl)-5-(hydroxymethyl)pyridin-2-yl]but-3-yn-2-one (from Step E above, 1.0 g) in TMEDA was heated to 110° C. until reaction completed. The mixture was concentrated and purified by silica gel (100% acetone) to give title compound as a yellow solid (0.46 g).

1. concentrationThe mixture was concentrated
2. custompurified by silica gel (100% acetone)