HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,6-Difluorophenyl)-1-[6-(2,4-difluorophenyl)-5-(hydroxymethyl)pyridin-2-yl]but-3-yn-2-one → HCID 16065181, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,6-Difluorophenyl)-1-[6-(2,4-difluorophenyl)-5-(hydroxymethyl)pyridin-2-yl]but-3-yn-2-one | HCID 57700377 | — |
| Solvent | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| Product | HCID 16065181 | HCID 16065181 | 46% |
Reaction Steps
To a solution of 1-(2,6-difluorophenyl)-1-[6-(2,4-difluorophenyl)-5-(hydroxymethyl)pyridin-2-yl]but-3-yn-2-one (from Step E above, 1.0 g) in TMEDA was heated to 110° C. until reaction completed. The mixture was concentrated and purified by silica gel (100% acetone) to give title compound as a yellow solid (0.46 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879875B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-f36db26aa3834fb09874c1937aa7f15d |
| Source note | uspto-grants-2011_02 |