反应详情

To a solution of 6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-7-(hydroxymethyl)-2H-quinolizin-2-one (Example 52, 21 mg) was added Dess-Martin periodinane (30 mg) at room temperature and stirred for 12 h. The mixture was concentrated and purified by silica gel (methylene chloride/methanol=20/1) to give the title compound (8 mg).

1. concentrationThe mixture was concentrated
2. custompurified by silica gel (methylene chloride/methanol=20/1)