HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triacetoxyperiodinane → 6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2-oxo-2H-quinolizine-7-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triacetoxyperiodinane | HCID 159087 | — |
| Reactant | 6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-7-(methoxymethyl)-2H-quinolizin-2-one | HCID 16065312 | — |
| Product | 6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2-oxo-2H-quinolizine-7-carbaldehyde | HCID 16065316 | 39.6% |
Reaction Steps
To a solution of 6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-7-(hydroxymethyl)-2H-quinolizin-2-one (Example 52, 21 mg) was added Dess-Martin periodinane (30 mg) at room temperature and stirred for 12 h. The mixture was concentrated and purified by silica gel (methylene chloride/methanol=20/1) to give the title compound (8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879875B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-bf329f5d4b6846b6af57654602f21b45 |
| Source note | uspto-grants-2011_02 |