HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1360790Generated: November 1, 2026
Methyl N-(triethylammoniosulfonyl)carbamate → Methyl 3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-indol-2-yl}-3,5-dimethylphenyl)-propionate
https://huagongshe.com/reaction/1360790
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl N-(triethylammoniosulfonyl)carbamate | HCID 2724994 | — |
| Reactant | Methyl 3-(4-{6-[N'-(4-methoxybenzoyl)-hydrazinocarbonyl]-1H-indol-2-yl}-3,5-dimethyl-phenyl)-propionate | HCID 66966407 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-indol-2-yl}-3,5-dimethylphenyl)-propionate | HCID 66966783 | — |
Reaction Steps
A mixture of methyl 3-(4-{6-[N′-(4-methoxybenzoyl)-hydrazinocarbonyl]-1H-indol-2-yl}-3,5-dimethyl-phenyl)-propionate (220 mg, 440 μmol) and Burgess reagent (210 mg, 880 μmol) in THF (10 mL) was heated in a microwave apparatus at 150° C. for 30 min. The solvent was removed under reduced pressure, and the residue chromatographed using a 30-70% gradient of heptane/ethyl acetate to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07879850B2 |
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| Source dataset | uspto-grants-2011_02 |
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| ORD ID | ord-519531fc323d4d05bc75bdc018a12c49 |
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| Source note | uspto-grants-2011_02 |
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