HRID1360790

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2724994

未命名化合物

结构：COC(=O)CCc1cc(C)c(-c2cc3ccc(C(=O)NNC(=O)c4ccc(OC)cc4)cc3[nH]2)c(C)c1

HCID66966407

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1cc(C)c(-c2cc3ccc(-c4nnc(-c5ccc(OC)cc5)o4)cc3[nH]2)c(C)c1

HCID66966783

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 150 °C

PROCEDURE

实验过程

A mixture of methyl 3-(4-{6-[N′-(4-methoxybenzoyl)-hydrazinocarbonyl]-1H-indol-2-yl}-3,5-dimethyl-phenyl)-propionate (220 mg, 440 μmol) and Burgess reagent (210 mg, 880 μmol) in THF (10 mL) was heated in a microwave apparatus at 150° C. for 30 min. The solvent was removed under reduced pressure, and the residue chromatographed using a 30-70% gradient of heptane/ethyl acetate to afford the title compound.

WORKUP

后处理

customThe solvent was removed under reduced pressure
customthe residue chromatographed

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-519531fc323d4d05bc75bdc018a12c49
来源数据集: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07879850B2
来源说明: uspto-grants-2011_02

反应 SMILES

[CH3:1][O:2][C:3]1[CH:37]=[CH:36][C:6]([C:7]([NH:9][NH:10][C:11]([C:13]2[CH:21]=[C:20]3[C:16]([CH:17]=[C:18]([C:22]4[C:27]([CH3:28])=[CH:26][C:25]([CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])=[CH:24][C:23]=4[CH3:35])[NH:19]3)=[CH:15][CH:14]=2)=O)=[O:8])=[CH:5][CH:4]=1.CC[N+](S(N=C(OC)[O-])(=O)=O)(CC)CC>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]2[O:8][C:11]([C:13]3[CH:21]=[C:20]4[C:16]([CH:17]=[C:18]([C:22]5[C:27]([CH3:28])=[CH:26][C:25]([CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])=[CH:24][C:23]=5[CH3:35])[NH:19]4)=[CH:15][CH:14]=3)=[N:10][N:9]=2)=[CH:36][CH:37]=1