Dimethylformamide → 1-Bromo-2-(phenoxymethyl)benzene

HRID 1360843Notes

Reaction equation

HRID 1360843 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.CN(C)[CH:12]=[O:13]>>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:13][C:12]1[CH:8]=[CH:9][CH:2]=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 769652-Bromobenzyl bromide

Product 1

HCID 131696961-Bromo-2-(phenoxymethyl)benzene

Procedure

The mixture is stirred at room temperature and 37.2 g of 2-bromobenzyl bromide in solution in 15 ml of dimethylformamide are introduced at 5° C. After 2 hours at 20° C., the reaction medium is poured over ice-cold water and extracted with ethyl acetate. The organic phase is dried over anhydrous sodium sulfate and concentrated to give 36 g of oil.

Workup

  1. additionthe reaction medium is poured over ice-cold water
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic phase is dried over anhydrous sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-b3d38276c1a948feb0d5a60e44ae9790
Source dataset
uspto-grants-2011_02
Patent number
US07879889B2

Reaction notes

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