反应详情

温度

25 °C

To a solution of 4-fluoro-3,5-dimethyl-benzaldehyde (1.0 g, 6.4 mmol) in 20 mL DCM was added mCPBA (1.2 g, 7.6 mmol) at 25° C. After being stirred for 20 h at 25° C., the reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate. The mixture was extracted DCM (3×30 mL) and the combined DCM layer was washed with brine (2×30 mL). The solution was dried over Na2SO4 before being concentrated under reduced pressure. The crude product was used directly in the next reaction without further purification.

1. customthe reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate
2. extractionThe mixture was extracted DCM (3×30 mL)
3. washthe combined DCM layer was washed with brine (2×30 mL)
4. dry with materialThe solution was dried over Na2SO4
5. concentrationbefore being concentrated under reduced pressure
6. customThe crude product was used directly in the next reaction without further purification