反应详情

170 g (506 mmol) of methyl (triphenylphosphoranylidene)acetate are added to a solution of 114 g (337 mmol) of 3-benzyloxy-4-iodobenzaldehyde in 570 ml of toluene. The reaction mixture is refluxed for 2 hours. The solvent is evaporated off and the oil obtained is purified by chromatography on a column of silica eluted with a 50/50 heptane/dichloromethane mixture. 115 g (87%) of methyl(E)-3-(3-benzyloxy-4-iodophenyl)acrylate are obtained in the form of pale yellow crystals.

1. temperatureThe reaction mixture is refluxed for 2 hours
2. customThe solvent is evaporated off
3. customthe oil obtained
4. customis purified by chromatography on a column of silica
5. washeluted with a 50/50 heptane/dichloromethane mixture