反应详情

47 ml (411 mmol) of benzyl chloride are added to a solution of 104 g (374 mmol) of methyl 3-hydroxy-4-iodobenzoate and 103 g (748 mmol) of potassium carbonate in 600 ml of methyl ethyl ketone, and the reaction medium is then refluxed for 8 hours. After cooling, the reaction medium is filtered, the precipitate is rinsed with ethyl acetate and the filtrate is evaporated to dryness. The residue is taken up in a mixture of water and ethyl acetate. The organic phase is dried over sodium sulfate, filtered and evaporated. 139 g (100%) of methyl 3-benzyl-4-iodobenzoate are obtained in the form of a white solid.

1. temperaturethe reaction medium is then refluxed for 8 hours
2. temperatureAfter cooling
3. filtrationthe reaction medium is filtered
4. washthe precipitate is rinsed with ethyl acetate
5. customthe filtrate is evaporated to dryness
6. additionThe residue is taken up in a mixture of water and ethyl acetate
7. dry with materialThe organic phase is dried over sodium sulfate
8. filtrationfiltered
9. customevaporated