Diethylamine → HCID 59278268, compound

HRID 1361194Notes

Reaction equation

HRID 1361194 reaction equation
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:25]([O:27][CH3:28])=[O:26])[C@@H:3]([CH3:24])[O:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(NCC)C>C(#N)C>[NH2:1][C@H:2]([C:25]([O:27][CH3:28])=[O:26])[C@@H:3]([CH3:24])[O:4][C:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 59278391HCID 59278391, compound

Product 1

HCID 59278268HCID 59278268, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of Fmoc-L-Thr(Trt)-OMe (2.40 g, 4.00 mmol) in acetonitrile (20.0 mL) was added diethylamine (20.0 mL). After 30 minutes, the mixture was concentrated in vacuo and the residue was diluted with acetonitrile (3×10 mL) and azeotroped in vacuo to afford L-Thr(Trt)-OMe which was used without further purification.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. additionthe residue was diluted with acetonitrile (3×10 mL)
  3. customazeotroped in vacuo

Sources & evidence

ORD record
ord-dc7cf78b88254bcb9497f4c60c206fd8
Source dataset
uspto-grants-2011_02
Patent number
US07879873B2

Reaction notes

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