Hydrochloric Acid → 1-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)

HRID 1361219Notes

Reaction equation

HRID 1361219 reaction equation
[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH:8]S(C(C)(C)C)=O)[O:4][N:3]=1.[ClH:15].O1CCOCC1>CO>[ClH:15].[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH2:8])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727644HCID 66727644, compound

Product 1

HCID 212922721-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid (3-bromo-isoxazol-5-ylmethyl)-amide (128 mg, 0.455 mmol) in MeOH (5 mL) was added a 4 M solution of HCl in dioxane (0.350 mL, 1.40 mmol) dropwise. After 2 hours and 10 minutes, the reaction mixture was concentrated in vacuo to afford the title compound which was used without further purification.

Workup

  1. concentration10 minutes, the reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-cba025b4b38c40ea98dcfedc82f80095
Source dataset
uspto-grants-2011_02
Patent number
US07879873B2

Reaction notes

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