Methyl iodide → HCID 16100378, compound

HRID 1361426Notes

Reaction equation

HRID 1361426 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)[CH2:8][CH2:7]1)[CH3:5].[CH:23](NC(C)C)(C)C.[Li].CI>C1COCC1>[CH3:1][O:2][C:3](=[O:22])[C:4]([CH3:23])([N:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:21])[F:19])=[CH:14][N:13]=2)[CH2:10][CH2:11]1)[CH3:5]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 16100377HCID 16100377, compoundHCID 45051747Lithium diisopropylamine

Product 1

HCID 16100378HCID 16100378, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionic acid methyl ester (1.23 g, 3.9 mmoles) from Example 14A in dry THF (3 mL) was added dropwise to a −65° C. solution of 1.8 N lithium diisopropylamine (LDA) in dry THF (2.4 mL) and stirred at this temperature for 1 hour. Methyl iodide (0.49 mL, 7.88 mmoles) was added and the mixture was allowed to slowly warm to room temperature and stir for 2 hours at room temperature. The mixture was quenched with ice/water and partitioned with ethyl acetate. The aqueous layer was extracted with ethyl acetate (3×) and the combined organic extracts washed with water, dried (MgSO4), filtered and the filtrate concentrated under reduced pressure. The residue was purified (silica gel, 10-30% acetone in hexane) to provide the title compound as a yellowish solid.

Workup

  1. stirringstir for 2 hours at room temperature
  2. customThe mixture was quenched with ice/water
  3. custompartitioned with ethyl acetate
  4. extractionThe aqueous layer was extracted with ethyl acetate (3×)
  5. washthe combined organic extracts washed with water
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationthe filtrate concentrated under reduced pressure
  9. customThe residue was purified (silica gel, 10-30% acetone in hexane)

Sources & evidence

ORD record
ord-5a72923f13664f2a91df090e52b9866f
Source dataset
uspto-grants-2011_02
Patent number
US07880001B2

Reaction notes

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