Hydrochloric Acid → HCID 178432214, compound

HRID 1361455Notes

Reaction equation

C([O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=3)[C:13]=2[C:15]([F:18])([F:17])[F:16])[N:8]=[C:7]([CH3:31])[C:6]=1[CH3:32])(=O)C.[OH-].[Na+].O.Cl>C(O)C>[F:17][C:15]([F:16])([F:18])[C:13]1[C:12]([O:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][C:27]([F:28])([F:30])[F:29])=[CH:22][CH:21]=2)=[CH:11][CH:10]=[C:9]2[C:14]=1[C:5]([OH:4])=[C:6]([CH3:32])[C:7]([CH3:31])=[N:8]2

Participants

Conditions

Temperature: 50 °C

Procedure

4-Acetoxy-5-trifluoromethyl-6-(4-trifluoromethoxyphenoxy)-2,3-dimethyl-quinoline (1.5 g) prepared in Synthesis Example 2 was dissolved in 10 mL of ethanol. A 20% sodium hydroxide solution (10 mL) was added to the solution, and the mixture was stirred at 50° C. for 3 hr. This reaction mixture was added to 20 mL of water, and the mixture was neutralized with 1 N hydrochloric acid. The precipitated crystals were collected by filtration under the reduced pressure to give 1.34 g of 5-trifluoromethyl-6-(4-trifluoromethoxyphenoxy)-4-hydroxy-2,3-dimethyl-quinoline (yield 98.0%).

Workup

filtrationThe precipitated crystals were collected by filtration under the reduced pressure

Sources & evidence

ORD record: ord-1c8fe5a0620d498e8c5d497a390b6177
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07880006B2

Reaction notes

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