Potassium Carbonate → 4-Nitro-1-(4-trifluoromethoxyphenoxy)-2-trifluoromethylbenzene

Participants

Reaction Conditions

Reaction Steps

A mixed solution composed of 44.3 g of 1-chloro-4-nitro-2-trifluoromethylbenzene, 98 mL of N,N-dimethylacetamide, 35 g of 4-trifluoromethoxyphenol, and 20.4 g of potassium carbonate was stirred with heating at 90 to 100° C. for 3 hr. This reaction solution was concentrated under the reduced pressure. Ethyl acetate was then added to and dissolved in the residue, and the solution was washed with brine. The solution was then concentrated under the reduced pressure. n-Hexane was added to the residue, and the precipitated crystals were collected by filtration to give 66.9 g of 4-nitro-1-(4-trifluoromethoxyphenoxy)-2-trifluoromethylbenzene (yield 92.7%).

Provenance & Evidence