反应详情

温度

95 °C

A mixed solution composed of 44.3 g of 1-chloro-4-nitro-2-trifluoromethylbenzene, 98 mL of N,N-dimethylacetamide, 35 g of 4-trifluoromethoxyphenol, and 20.4 g of potassium carbonate was stirred with heating at 90 to 100° C. for 3 hr. This reaction solution was concentrated under the reduced pressure. Ethyl acetate was then added to and dissolved in the residue, and the solution was washed with brine. The solution was then concentrated under the reduced pressure. n-Hexane was added to the residue, and the precipitated crystals were collected by filtration to give 66.9 g of 4-nitro-1-(4-trifluoromethoxyphenoxy)-2-trifluoromethylbenzene (yield 92.7%).

1. concentrationThis reaction solution was concentrated under the reduced pressure
2. additionEthyl acetate was then added to and
3. dissolutiondissolved in the residue
4. washthe solution was washed with brine
5. concentrationThe solution was then concentrated under the reduced pressure
6. additionn-Hexane was added to the residue
7. filtrationthe precipitated crystals were collected by filtration