Ethyl 2-(2-aminothiazol-5-ylthio)acetate → {2-[3-(4-Fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoylamino]-thiazol-5-ylsulfanyl}-acetic Acid Ethyl Ester

HRID 1361537Notes

Reaction equation

HRID 1361537 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[C:14]([O:16][C@@H:17]([CH3:21])[CH2:18][O:19][CH3:20])[CH:15]=2)[C:10]([OH:12])=O)=[CH:4][CH:3]=1.[CH2:24]([O:26][C:27](=[O:36])[CH2:28][S:29][C:30]1[S:34][C:33]([NH2:35])=[N:32][CH:31]=1)[CH3:25]>>[CH2:24]([O:26][C:27](=[O:36])[CH2:28][S:29][C:30]1[S:34][C:33]([NH:35][C:10](=[O:12])[C:9]2[CH:13]=[C:14]([O:16][C@@H:17]([CH3:21])[CH2:18][O:19][CH3:20])[CH:15]=[C:7]([O:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:23][CH:22]=3)[CH:8]=2)=[N:32][CH:31]=1)[CH3:25]

Participants

3

Reactant 2

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 669693723-(4-fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoic acid

Product 1

HCID 57776311{2-[3-(4-Fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoylamino]-thiazol-5-ylsulfanyl}-acetic Acid Ethyl Ester

Procedure

The title compound was prepared from 3-(4-fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoic acid and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester following general procedure A

Sources & evidence

ORD record
ord-ab6e067b5a4e4192ae6ce9a7bf477f70
Source dataset
uspto-grants-2011_02
Patent number
US07880012B2

Reaction notes

Loading…