3-(4-fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoic acid → 3-{2-[3-(4-Fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoylamino]-thiazol-4-ylmethylsulfanyl}-propionic acid ethyl ester

HRID 1361555Notes

Reaction equation

HRID 1361555 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[C:14]([O:16][C@@H:17]([CH3:21])[CH2:18][O:19][CH3:20])[CH:15]=2)[C:10]([OH:12])=O)=[CH:4][CH:3]=1.[CH2:24]([O:26][C:27](=[O:38])[CH2:28][CH2:29][S:30][CH2:31][C:32]1[N:33]=[C:34]([NH2:37])[S:35][CH:36]=1)[CH3:25]>>[CH2:24]([O:26][C:27](=[O:38])[CH2:28][CH2:29][S:30][CH2:31][C:32]1[N:33]=[C:34]([NH:37][C:10](=[O:12])[C:9]2[CH:13]=[C:14]([O:16][C@@H:17]([CH3:21])[CH2:18][O:19][CH3:20])[CH:15]=[C:7]([O:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:23][CH:22]=3)[CH:8]=2)[S:35][CH:36]=1)[CH3:25]

Participants

3

Reactant 2

HCID 669693723-(4-fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoic acidHCID 71414389Ethyl 3-{[(2-amino-1,3-thiazol-4-YL)methyl]sulfanyl}propanoate

Product 1

HCID 866323883-{2-[3-(4-Fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoylamino]-thiazol-4-ylmethylsulfanyl}-propionic acid ethyl ester

Procedure

3-{2-[3-(4-Fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoylamino]-thiazol-4-ylmethylsulfanyl}-propionic acid ethyl ester was prepared from 3-(4-fluoro-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoic acid and 3-(2-amino-thiazol-4-ylmethylsulfanyl)-propionic acid ethyl ester following general procedure A.

Sources & evidence

ORD record
ord-c24c92397ef14a94b50ff5b242aaf35f
Source dataset
uspto-grants-2011_02
Patent number
US07880012B2

Reaction notes

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