Ethanolamine → HCID 66970356, compound

HRID 1361607Notes

Reaction equation

HRID 1361607 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[N+:13]([O-:15])=[O:14].[NH2:16][CH2:17][CH2:18][OH:19]>O1CCCC1>[N+:13]([C:4]1[CH:5]=[C:6]([C:9]([F:12])([F:11])[F:10])[CH:7]=[CH:8][C:3]=1[CH2:2][NH:16][CH2:17][CH2:18][OH:19])([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 27757862-Nitro-4-(trifluoromethyl)benzyl chloride

Product 1

HCID 66970356HCID 66970356, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a sealed tube, added 1-(chloromethyl)-2-nitro-4-(trifluoromethyl)benzene (2.0 g, 8.4 mmol), tetrahydrofuran (8.4 mL), and 2-aminoethanol (5.0 mL, 83.5 mmol). Stirred the mixture at room temperature for 45 minutes. Extracted the mixture into ethyl acetate, washed 2 times with water, 1 time with brine solution, dried over magnesium sulfate, filtered, concentrated to yield 2-(2-nitro-4-(trifluoromethyl)benzylamino)ethanol. MS (M+H)+=265; Calc'd 264.21 for C10H11F3N2O3.

Workup

  1. extractionExtracted the mixture into ethyl acetate
  2. washwashed 2 times with water, 1 time with brine solution
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-6395d46454c0406e9c9b65871efd0372
Source dataset
uspto-grants-2011_02
Patent number
US07880000B2

Reaction notes

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