Cyanogen Bromide → HCID 66970354, compound

HRID 1361608Notes

Reaction equation

HRID 1361608 reaction equation
[N+:1]([C:4]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:5]=1[CH2:6][NH:7][CH2:8][CH2:9][OH:10])([O-:3])=[O:2].[N:19]#[C:20]Br>O1CCCC1>[N+:1]([C:4]1[CH:14]=[C:13]([C:15]([F:16])([F:17])[F:18])[CH:12]=[CH:11][C:5]=1[CH2:6][N:7]1[CH2:8][CH2:9][O:10][C:20]1=[NH:19])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 10476Cyanogen BromideHCID 66970356HCID 66970356, compound

Product 1

HCID 66970354HCID 66970354, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a sealed tube, added 2-(2-nitro-4-(trifluoromethyl)benzylamino)ethanol (Step 1, 1.10 g, 4.16 mmol), cyanogen bromide (1.32 g, 12.4 mmol), and tetrahydrofuran (4.2 mL). Stirred at room temperature for 56 hours. Concentrated down to yield 3-(2-nitro-4-(trifluoromethyl)benzyl)oxazolidin-2-imine. MS (M+H)+=290; Calc'd 289.22 for C11H10F3N3O3.

Workup

  1. concentrationConcentrated down

Sources & evidence

ORD record
ord-5df15ecf7c9042a088fb592c7e64c716
Source dataset
uspto-grants-2011_02
Patent number
US07880000B2

Reaction notes

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