Triethylamine → HCID 58588060, compound

HRID 1361689Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][C:22]=1[Cl:23])[O:5][C:6]1[C:11]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([NH:18][CH3:19])[CH:13]=2)=[CH:10][CH:9]=[CH:8][N:7]=1.[F:24][C:25]1[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:26]=1[C:27](Cl)=[O:28].C(N(CC)CC)C>C(Cl)(Cl)Cl>[Cl:23][C:22]1[CH:21]=[CH:20][C:4]([O:5][C:6]2[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([NH:18][CH3:19])[CH:13]=3)=[CH:10][CH:9]=[CH:8][N:7]=2)=[CH:3][C:2]=1[NH:1][C:27](=[O:28])[C:26]1[CH:30]=[C:31]([C:34]([F:35])([F:36])[F:37])[CH:32]=[CH:33][C:25]=1[F:24]

Participants

Conditions

Temperature: 75 °C

Procedure

In a sealed tube, [2-(3-Amino-4-chloro-phenoxy)-[3,4′]bipyridinyl-2′-yl]-methyl-amine (300 mg, 0.918 mmol) and 2-Fluoro-5-trifluoromethyl-benzoyl chloride (0.180 mL, 1.19 mmol) were dissolved in 2.0 mL chloroform. The solution was heated to 75° C. and stirred for 48 h. The reaction was then cooled to RT, quenched with triethylamine (0.128 mL, 0.918 mmol), and concentrated in vacuo to yield the title compound as a crude light yellow solid. MS m/z (M+H)+=517; Calc'd 516.87 for C25H17ClF4N4O2.

Workup

temperatureThe reaction was then cooled to RT
concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-1dfd803df74c471195a908cda5893621
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07880000B2

Reaction notes

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