Ammonium Hydroxide → 2-fluorobenzene-1,4-diamine

HRID 1361694Notes

Reaction equation

HRID 1361694 reaction equation
FC1C=C(N)C=CC=1F.[F:10][C:11]1[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][C:12]=1[NH2:18].[NH4+].[OH-]>>[F:10][C:11]1[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][C:12]=1[NH2:18]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 66970652HCID 66970652, compound

Product 1

HCID 3453722-fluorobenzene-1,4-diamine

Conditions

Temperature
150 °C

Procedure

Preparation of 2-fluorobenzene-1,4-diamine 3,4-Difluorobenzenamine (3.0 mL) and NH4OH (15.0 mL) were heated in a sealed tube at 150° C. with vigorous stirring for several hours, forming a solid yellow precipitate. The reaction was filtered, washed with water, and then hexanes to afford 2-fluorobenzene-1,4-diamine as a yellow solid.

Workup

  1. customforming a solid yellow precipitate
  2. filtrationThe reaction was filtered
  3. washwashed with water

Sources & evidence

ORD record
ord-6fc3cab6b08143eea275691b93a46743
Source dataset
uspto-grants-2011_02
Patent number
US07880000B2

Reaction notes

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